99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer

Product description Name:AZD-9291Synonyms:N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;AZD9291;CAS:1421373-65-0 MF:C28H33N7O2&nb

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99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer
Product description
 
Name:AZD-9291
Synonyms:N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;AZD9291;
CAS:1421373-65-0 
MF:C28H33N7O2 
MW:499.61 
Feature:Orally bioavailable mutant-selective EGFR inhibitor that has been tested in Phase III clinical trials for treatment of Non-Small Cell Lung Cancer.
 
Applications
 
AZD9291 administered once daily orally at 5 mg/kg caused profound regression of tumours across EGFRm+ (PC9; 178% growth inhibition) and EGFRm+/T790M (H1975; 119% growth inhibition) tumour models in vivo,after 14 days dosing. Furthermore 5 mg/kg AZD9291 was sufficient to cause significant shrinkage of EGFRm+ and EGFRm+/T790M transgenic mouse lung tumours. Tumour growth inhibition was associated with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK. Chronic long-term treatment of PC9 and H1975 xenograft tumours with AZD9291 led to a complete and sustained macroscopic response, with no visible tumours after 40 days dosing, and being maintained beyond 100 days. Furthermore, pre-clinical data also indicates that AZD9291 could target tumours that have acquired resistance to the more recently identified HER2-amplification mechanism, thus potentially extending its benefit in TKI resistant patients.

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99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer


99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer

 

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Xi'an Tian guangyuan Biotech Co.,Ltd.

Tel: 86-29-86333380

Fax: 86-29-86333380

Web:tgybio.en.made-in-china.com


 

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99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer
 

 

Company information

XIAN Tian Guangyuan Biotech Co.,Ltd.was founded in May 2003, is a professional animal and plant extracts modern and advanced enterprise object, chemical intermediates and active ingredients of natural active throughout the country, plant extracts industry, research and development, production, marketing and other areas have a strong strength. The company is headquartered in the outskirts of Xi'an, under research and development center as well as analysis and testing center, comprehensive strength in the national forefront of the industry. Companies rely on the wisdom and innovation of advanced technology, scientific management and all the staff and a good team spirit, will enable the company to develop a domestic industry with sik-class product quality and international competitiveness of enterprises.

 


99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer

99% Purity Pharmaceutical Raw Osimertinib Powder Azd-9291 Mesylate for Lung Cancer

 

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We have more than 500 vendors, we could save your effort to serve customers with supplying all your needs!

1. We has 10 years' exporting experience in active pharmaceutical ingredient products.
    Our professionaland thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

1> Any inquiries will be replied within 12 hours.
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We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

 

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