Infiltration Anesthesia/Epidural Anesthesia/Surface Anesthesia Linocaine Hydrochloride

Basic Information
Description

1. Lidocaine hcl is a local anesthetic and antiarrhythmic drug. It is clinically used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including in the thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block.
2. Lidocaine hcl is an amide local anesthetic. With the dose increased, the role or toxicity increased, there is an anti-convulsive effect with sub-poisoning plasma concentration; Blood concentration of more than 5μg • ml-1 can occur convulsions.
3. Lidocaine hcl in low doses can promote outflow of K+ in cardiomyocytes, reduce myocardial autonomy, and has antiarrhythmic effects. Increased plasma concentration may cause slowing of heart conduction, atrioventricular block, inhibition of myocardial contractility and decreased cardiac output.

 
Function

This medication is used on the skin to stop itching and pain from certain skin conditions (e.g., scrapes, minor burns, eczema, insect bites) and to treat minor discomfort and itching caused by hemorrhoids and certain other problems of the genital/anal area (e.g., anal fissures, itching around the vagina/rectum). Some forms of this medication are also used to decrease discomfort or pain during certain medical procedures/exams (e.g., sigmoidoscopy, cystoscopy). Lidocaine hcl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

Usage
Lidocaine is a local anesthetic, also called Xylocaine, in recent years has been replaced by procaine, widely used in cosmetic surgery in local anesthesia, through the sodium channel inhibition of nerve cell membranes to blockade the nerve excitability and conduction. Its fat solubility and protein binding rate were higher than procaine, with strong ability to penetrate cells, fast acting, long action time and 4 times the effect of procaine.
Lidocaine can also be used to treat ventricular premature beats, ventricular tachycardia, Yu Yang Rehmannia poisoning, cardiac surgery and cardiac catheter induced ventricular arrhythmias after acute myocardial infarction, including ventricular premature beat, ventricular tachycardia and ventricular fibrillation. The second is also used in the status of the status epilepticus with other anticonvulsant drugs and local or intraspinal anaesthesia. However, supraventricular arrhythmia is usually ineffective.

Application
Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though there is not enough study evidence to recommend it as a first-line treatment. IV lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two thirds.
Lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.

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Our Company
Wuhan Biocar Pharmaceutical Co., Ltd. is a hightech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.

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