O'Connor JB etc. Public Science Library One. 2021; doi: 10.1371/journal.pone.0257838.
O'Connor JB etc. Public Science Library One. 2021; doi: 10.1371/journal.pone.0257838.
Researchers reported in PLOS ONE that lower respiratory tract samples from cystic fibrosis patients of different ages have significant differences in respiratory tract microbiota and inflammation.
"We compared bronchoscopy of lower respiratory tract samples of children with cystic fibrosis and disease controls of different age groups, and used gene sequencing to identify microorganisms. We found that some common cystic fibrosis pathogens began to dominate at a very young age. Status," John B. O'Chicago Ann & Robert H. Lurie Children’s Hospital Clinical Research Assistant in the Pediatric Pulmonary and Sleep Medicine Department, Conner, Massachusetts, said in a related press release. "In this young age group, there is such a clear divergence between disease control and disease control that has never happened before."
The researchers evaluated clinical data and bronchoalveolar lavage fluid samples from 191 participants younger than 21 years of age. The researchers measured the total bacterial load and performed genetic sequencing to characterize the bacterial communities in the sample and have species-level sensitivity to the selected genera.
63 patients had cystic fibrosis (average age 9.7 years; 65% were women). Researchers report that samples from patients with cystic fibrosis have higher bacterial loads and lower microbial diversity. In addition, according to the results, these samples are also different from the disease control of 2 to 5 years old, and the neutrophil inflammation is higher relative to the bacterial load.
The researchers observed that in the samples of elderly participants with cystic fibrosis, traditional cystic fibrosis pathogens increased, while the types of Streptococcus palliatives, Oral Streptococcus, and Streptococcus pneumoniae decreased. The most common species-level taxa are S. mitis/oralis/pneumoniae (52%) and Prevotella melaninogenica (44%).
The researchers wrote that the diversity of heterogeneous disease control independent of cystic fibrosis diagnosis and indications has increased.
Compared with cystic fibrosis patients, antibiotic exposure was more common in control participants (90% vs. 45%; P <.001). Antibiotic exposure was associated with lower neutrophil inflammation (P = .002) and lower bacterial load (P = .049).
There were no significant differences in bacterial diversity and lung function between participants who received antibiotic treatment and participants who did not receive antibiotic treatment.
The researchers wrote: "A deeper assessment of the airway microbiome and how it triggers inflammation early in life may provide valuable insights into the development of cystic fibrosis lung disease, and possible interventions to slow the progression of the disease. ."
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